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Pramlintide as adjunct therapy for the treatment of type 1 diabetes

Where are we today?

Insulin treatment for type 1 diabetes mellitus (T1D) has improved over the past decades due to advances in insulin formulations and administration techniques. Nevertheless, optimal glucose control and reaching HbA1c goals remain challenging for many patients. Consequently, the risk of subsequent micro- and macrovascular complications remains high and life expectancy is still reduced in this patient group so that there is an obvious need for improvement of current therapies or the development of new, additional treatments [1]. So what else can be done?

 

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Topics: Clinical Trials in Diabetes, Treating Diabetes

Posted by Dr. Susanne Famulla on Dec 19, 2018 5:12:00 PM
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Vitamin D supplementation – is there a role in type 1 diabetes?

The possible ‘non-calcemic’ effects of Vitamin D in numerous diseases has become a large area of research. Historically, Vitamin D is known for its regulatory role in calcium absorption and bone metabolism but the identification of vitamin D receptor (VDR) expression in more than 30 tissues led to the possibility of pleiotropic effects of vitamin D [Diabetes Forouhi 2008]. In vitro and animal studies suggested an anti-inflammatory and immunomodulatory effect of Vitamin D [The Review of Diabetic Studies, Gregoriu 2017]. Moreover, preclinical studies uncovered a potential regulatory role of Vitamin D in insulin secretion, β-cell survival and calcium flux in pancreatic β-cells [Mitri J, Endocrinol Metab Clin North Am 2014].

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Topics: The Science behind Diabetes

Posted by Dr. Susanne Famulla on May 30, 2018 4:52:37 PM
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Lipohypertrophy - The ugly side of insulin injection practice

Lipohypertrophy - Background

Lipohypertrophy (LHT) is a common side effect of long-standing insulin therapy in patients with diabetes mellitus. Lipohypertrophic lesions are characterised by a palpable tumour-like thickening of subcutaneous adipose tissue. Cross-sectional studies from different countries such as Germany, Ethiopia and Spain reported prevalences of LHT ranging between 28% to over 64% predominantly in patients with type 1 diabetes mellitus. Although the exact aetiology of LHT is unclear, factors such as duration of insulin treatment, needle reuse and frequent injection into same tissue areas due to missing or wrong injection site rotation may play an important role in the development of LHTs. In particular the latter factor, incorrect injection and rotation techniques, are widely observed in clinical daily practice. Patients with LHTs often state that insulin administration into same areas make insulin therapy easier due to easy access and/or less pain in the usually chosen injection sites. 

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Topics: Clinical Trials in Diabetes

Posted by Dr. Susanne Famulla on May 6, 2015 1:13:00 PM
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