Contact
Header_1077x260px_About_Profil.jpg

Artificial Intelligence to Screen for Diabetic Retinopathy; The Times They Are A-Changin‘.

The far majority of clinical trials in diabetes exclude patients with active retinal disease, as interventions that lower glucose rapidly can temporarily worsen retinopathy. This was originally shown in type 1 diabetes [1] but more recently also in type 2 diabetes [2, 3]. Screening for diabetic retinopathy before inclusion in a clinical trial is relatively cumbersome, also because it often involves a separate visit to an ophthalmologist. The use of a fundus camera with offline interpretation by an ophthalmologist has gained widespread use in clinical practice, but not so much in the field of clinical trials.

In this blog I will briefly describe four recent studies on artificial intelligence approaches to automate the interpretation of retinal images. I will conclude with an outlook on how this may facilitate the screening of potential trial participants for diabetic retinopathy. But first a brief introduction to deep learning, the methodology applied in all these papers.

Read More

Topics: Treating Diabetes, The Science behind Diabetes, Diabetes Technology

Posted by Prof. Hans de Vries on Oct 23, 2018 5:18:00 PM
prof-hans-de-vries

New timelines for the EU Portal and implementation of the EU Clinical Trial Regulation

The EU Clinical Trial Regulation No 536/2014 (CTR), which aims to harmonise the assessment and supervision for clinical trials throughout EU Member States, was originally planned to come into application this month (October 2018). As reported earlier, the implementation of the CTR depends on the availability of a functional EU Portal, the single entry point for submitting clinical trial information in the EU, and database.

Read More

Topics: Clinical Trials in Diabetes

Posted by Dr. Grit Andersen on Oct 17, 2018 5:12:00 PM
dr-grit-andersen

"Profil World" - The clinical diabetes research newsletter - October 2018

Dear all,

Greetings from Germany! I am happy to share with you the newest edition of "Profil World" - our newsletter filled with information about clinical research in diabetes and obesity.

Read More

Topics: About Profil

Posted by Dr. Lars Bochmann on Oct 11, 2018 5:21:00 PM
dr-lars-bochmann

54th EASD Annual Meeting – Profil’s contributions to the scientific sessions

Berlin, Germany, 1-5 October 2018

Last week our team joined an exciting and busy 54th EASD Annual Meeting in Berlin. We would like to give you a brief overview about those orals and posters presenting results from clinical trials Profil had been involved in.

Read More

Topics: Treating Diabetes, Diabetes Technology, The Science behind Diabetes

Posted by Dr. Sabine Arnolds on Oct 10, 2018 4:15:43 PM
dr-sabine-arnolds

Profil explores opportunities for artificial pancreas in type 2 diabetes

Highlighting the role of open and trans-sectoral collaboration in the advancement of artificial pancreas solutions

Profil has recently published a peer-reviewed article on the topic of “Artificial Pancreas Systems for People With Type 2 Diabetes: Conception and Design of the European CLOSE Project ” in the Journal of Diabetes Science and Technology. Profil is the organisation coordinating CLOSE. The article is authored by CLOSE industry and academic partners, representatives of the EIT Health public-private partnership management boards, and key opinion leaders in the field.

Read More

Topics: Treating Diabetes, Diabetes Technology, The Science behind Diabetes

Posted by Prof. Dr. Freimut Schliess on Oct 2, 2018 5:18:00 PM
prof-dr-freimut-schliess

Work stress is the new smoking

According to the WHO, about 31% of all deaths worldwide (17.7 million deaths per year) [1] are attributable to cardiovascular disease (CVD), making CVDs the number 1 cause of death globally. Known risk factors for the development of CVD, among others, are smoking, high blood pressure or the lack of physical activity. Especially the latter has been discussed in the recent years and it became known that long hours of sitting [2] may increase your risk of CVD and diabetes (and may apparently even increase mortality, in the case of binge watching [3]). While numerous risk factors for CVD are known and several recommendations and guidelines on how to handle them exist, the prognostic role of what may possibly be one of the most common and important factors on cardiovascular health nowadays has not yet been formally assessed: stress at work.

Read More

Topics: Treating Diabetes, Clinical Trials in Diabetes

Posted by Dr. Theresa Herbrand on Sep 25, 2018 5:12:00 PM
dr-theresa-herbrand

Profil at EASD Annual Meeting 2018

About EASD Annual Meeting

Profil will be present at EASD Annual Meeting with numerous posters as well as some presentations. Of course we look forward to this exciting event very much. 

We are proud that Profil will be a sponsor of Solvable Problems in Diabetes at EASD Annual Meeting 2018 in Berlin. The event will take place on Thursday, October 4, 2018, from 7:00-9:00 pm during the 2018 annual meeting for the European Association of the Study of Diabetes (EASD). Learn more about the event here

To meet Profil at the EASD Annual Meeting please fill out the request form at our website.

Read More

Topics: About Profil

Posted by Dr. Lars Bochmann on Sep 14, 2018 12:21:35 PM
dr-lars-bochmann

Do-It-Yourself Artificial Pancreas systems (DIY APS)

The way forward to closed-loop metabolic control in diabetes care?

The challenge

Diabetes represents a huge and multidimensional challenge. Despite the availability of numerous treatment options, many patents still fail to reach their treatment goals. Administration of  the right amount of insulin at the right time still poses a great challenge for the self-management of many people with diabetes.

Accordingly there is a huge need to implement new innovative products and services improving both the effectiveness of diabetes care and the quality of life for people with diabetes. Particularly user-centered products and sercvices co-created with stakeholders including people with diabetes may have a high potential to increase treatment adherence thereby reducing the enormous pressure on healthcare systems.

Read More

Topics: Diabetes Technology, Treating Diabetes, The Science behind Diabetes

Posted by Prof. Dr. Freimut Schliess on Sep 5, 2018 5:16:00 PM
prof-dr-freimut-schliess

Targeting the incretin/glucagon system: a glimmer of hope

Dual- and multi-receptor agonists may be a novel drug class to treat obesity and type 2 diabetes mellitus with high efficacy

The rising prevalence of obesity has metabolic consequences such as diabetes and cardiovascular complications. Many existing therapies for type 2 diabetes mellitus (T2DM) focus on lowering blood glucose; however, there is a major unmet need for treatments that both improve glycemic control and achieve metabolic benefits by weight loss. Lifestyle interventions, such as dieting and physical activity, typically provide only short-lasting weight loss in obese people, as weight loss maintenance is the greatest barrier to successful treatment of obesity [1].

 

Read More

Topics: Treating Diabetes

Posted by Dr. Ulrike Hövelmann on Aug 28, 2018 5:11:00 PM
dr-ulrike-hövelmann

Free webinar on EU-funded R&D partnerships in healthy living and active ageing

Profil continues the successful series of scientific webinars. On September 12th we will air our webinar on "EU-funded R&D partnerships in healthy living and active ageing". The session is presented by Prof. Dr. Freimut Schliess, Director Science & Innovation at Profil and Jakob Haardt, Research & Innovation Manager at Eurice. 

Read More

Topics: About Profil

Posted by Svenya Meister on Aug 14, 2018 5:18:00 PM
svenya-meister

Subscribe to our monthly blog updates

New Call-to-action

Subscribe to Email Updates

Our most popular Posts