Profil continues the successful series of scientific online seminars. On February 19th, 2020 we will air our free online seminar on early phase obesity research. The session is presented by Dr. Daniela Lamers, Nutritional Science Specialist at Profil.
Our experts will talk about early phase obesity research and how to measure outcomes of interest. While watching the online seminar you will benefit by learning about obesity facts and background (present situation and estimates for the future), current trends in obesity research (new drug development / other strategies for weight loss, cadiovascular outcome studies) and endpoints which should be measured while planning an obesity trial.
Here is the online seminar's synopsis:
It is well known that obesity and overweight are highly contributing to a marked increase in type 2 diabetes. However, despite increasing obesity rates, the number of new diabetes cases seems to decline - this is the outcome of a report published in May this year, analysing new federal data of U.S. adults. According to these studies 1.3 million new diabetes diagnoses were made in 2017, compared to 1.7 million in 2009. After an almost 20-year increase in the national prevalence and incidence of diagnosed diabetes cases (1990-2009), an 8-year period of stable prevalence and a decrease in incidence has occurred.
Even though the underlying mechanics for this phenomenon are not fully understood, one important contributing factor is thought to be increasing efforts to identify and treat overweight and obese individuals at high metabolic risk (prediabetes).Although so-called lifestyle changes - comprising diet and an increase in physical activity - are still the first line approach, the past years have seen approval of quite a few novel anti-obesity drugs. The majority of these influence hypothalamic appetite pathways via dopaminergic or serotoninergic signalling or mimic endogenous satiety signals using long-lasting forms of peripheral appetite suppressing hormones. There is also considerable interest in targeting thermogenesis by brown adipose tissue to increase resting energy expenditure. Obesity pharmacotherapy has seen several false dawns, but improved understanding of the pathways regulating energy balance, and better-designed trials give greater confidence that recently approved agents will be both efficacious and safe.
Hence, understanding the energy equation in terms of energy intake and energy expenditure is imperative for any given weight loss intervention. Profil’s metabolic ward is specialized in meeting nutritional requirements in clinical research. Our metabolic kitchen allows the investigation and control of the impact of nutritional conditions in clinical trials. To date, Profil has performed more than 70 studies with standardized nutritional regimens helping to match nutritional plans to the objectives of any trial, for example when mixed meal tolerance tests or individual diets are needed.
On the other side of the scale, also energy expenditure requires sophisticated methodology. Depending on the study design, total energy requirements can be determined based on resting metabolic rate, measured via indirect calorimetry or estimated with commonly used formulas using individual anthropometric measurements including body composition. In addition to resting energy expenditure, nutrient-induced thermogenesis and exercise-induced thermogenesis can be assessed via indirect calorimetry as contributing variables to total energy expenditure.
In addition, Profil provides the possibility to assess other outcome variables. The “classical” anthropometric parameters such as BMI and waist circumference can be extended to precise body composition measurements in terms fat and fat-free mass with the help of densitometry – air displacement plethysmography (BOD POD®). Recent evidence indicates an increase of liver fat as being another key factor predisposing obese people to the development of insulin resistance. Profil provides the measurement of liver fat directly using magnetic resonance spectroscopy (MRS) or indirectly using the fatty liver index (FLI), which is a composite surrogate of gamma-glutamyltransferase, triglycerides, waist circumference and BMI. Insulin resistance (IR) is a classical feature of prediabetes. It may be present years before deterioration in blood glucose control becomes measurable. In this regard, Profil uses the most accurate and reliable measure of insulin sensitivity: the hyperinsulinemic euglycemic clamp technique.
The experience and methodology at Profil's disposal, makes us experts in the area. Join this online seminar to get an overview of current trends in obesity research and available technologies and learn in detail about study designs in clinical trials.
If you are interested in our upcoming online seminar, don't wait to register for this online seminar as the available slots are limited. And don't worry if the date doesn't suit you. You will be able to watch a recording of the online seminar afterwards. To register now you can either follow this link or click on the button below.