Advancing Early-Phase Clinical Trials with Automated Euglycemic Glucose Clamps

Advancing Diabetes & Metabolic Research with Fully Automated Glucose Clamps

At Profil, we set the gold standard in clamp methodology with ClampArt®, our proprietary fully automated glucose clamp device. As the only CRO worldwide using fully automated clamps, we deliver unmatched precision in evaluating insulin action and glucose-lowering therapies.

What Makes Automated Euglycemic Glucose Clamps Essential?

This state-of-the-art technique ensures continuous, real-time blood glucose monitoring and automatically adjusts the glucose infusion rate (GIR) every minute. Unlike manual methods, ClampArt® eliminates investigator bias, ensuring superior data accuracy and consistency.

How it Works:

• Fully Automated Precision: Continuous glucose monitoring with minute-by-minute GIR adjustments.
• Standardized & Reproducible: Reduces variability and ensures high data quality.
• Efficient & Scalable: Profil’s advanced infrastructure enables the simultaneous execution of multiple glucose clamps, optimizing trial efficiency and data collection.

Key Benefits for Clinical Trials:

• Unmatched Accuracy: Eliminates human error, optimizing pharmacodynamic (PD) assessments.
• Enhanced Patient Safety & Comfort: Controlled glucose regulation ensures a smooth experience for participants.
• Comprehensive Insights: Evaluates insulin onset of action, peak action, duration of action, and variability with high precision.

Why Choose Profil?

With more glucose clamps performed than any other institution worldwide, Profil leads the way in early-phase trials for novel insulins, biosimilars, and glucose-lowering therapies. Our proprietary ClampArt® technology ensures gold-standard metabolic research that drives drug development forward.

Stay ahead of the innovation

Follow us for more insights on how Profil and ClampArt® are redefining clinical trial methodologies in metabolic research. Also you can watch our online seminar session about glucose clamps with ClampArt® here.